Metformin and weight loss have a long-standing link. First, it was noted that users who took the drug to control their blood glucose, also lost kilograms of weight. At first it was not known if this decrease in fat was due to diet or medication; however, it was a starting point for hypotheses.
One of the theories suggests that this drug has the ability to reduce appetite. Therefore, the calorie balance is in favor of weight loss. Anyway, it should be clear that it is not a strategy of choice to lose weight. For what reason? Here we explain it in detail.
What is metformin?
Metformin is an oral antidiabetic drug, that is, it is indicated as the first choice in people with type 2 diabetes. This form of the disease is one in which the use of injectable insulin is not yet required.
Its form of action focuses on preventing the amount of circulating glucose in the blood from rising. This is achieved by blocking the absorption of sugars in the intestine, which ultimately translates into less availability of the nutrient.
In addition, metformin also works in the liver, where it helps stop glucose production. It forces you to make glycogen, which is a storage form of sugar. Finally, another important point of action is in the muscle, where the sensitivity of this tissue to insulin improves.
Ultimately, the drug does not lower a person’s blood glucose, but rather prevents it from rising after meals. Therefore, their administration schedules are in relation to the big meals of the day. 500 to 800 milligrams are usually prescribed with lunch and dinner.
The most severe cases reach up to 1000 milligrams, twice a day, although at that point it is preferred to combine it with another oral hypoglycemic agent, such as glimepiride, glibenclamide, among others. The choice is very particular for each clinical picture.
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